PMF-source™ Citrus Flavonoids and Citrus Limonoids
Product Description:
Fruits and vegetables have demonstrated potential to help prevent some cardiovascular diseases, such as chronic inflammation. Citrus polymethoxylated flavones (PMFs) are a subclass of citrus bioflavonoids. They occur naturally in an extremely bioactive, potent molecule. This is especially true for tangeretin and nobiletin, two primary citrus PMFs. PMFs are similar to other plant pigments found in citrus fruits also linked to health benefits for their protection against heart disease and inflammation. Epidemiological studies have shown that consumption of dietary flavonoids is strongly associated with reduced incidence of cardiovascular and coronary problems. Limonoids are citrus bioactive compounds that have been found to have synergistic effects in preventing certain types of cardiovascular diseases.
SourceOne is proud to offer the highest-quality citrus PMFs and citrus Limonoids available on the market.
Market Opportunity:
More than ever, consumers are concerned about cardiovascular disease and risk, including high blood cholesterol levels. The need and demand for heart-healthy products is unprecedented. As more natural-based heart health and cholesterol products have demonstrated their benefits, consumers demand high-quality, science-based, effective products to support heart health.
SourceOne’s PMF-source™ Citrus Flavonoids and Citrus Limonoids offer proven, heart-healthy options. However, PMF’s are very poorly absorbed. SourceOne’s patented VESIsorb delivery system is ideally suited to maximize absorption and more effectively deliver the many benefits associate with PMF’s
Innovation:
SouceOne is a leader in introducing new innovations and scientific technologies that help deliver health and wellness through natural products. We are relentless in our pursuit of improvements in nutritional supplements, functional foods and beverages, cosmetics, and animal nutrition that offer better solutions to the growing need for healthy and nutritious wellness options. Our dedicated team of global research partners invests heavily in research and development (R&D) and scientific studies. They also work closely with major universities, medical institutions, and Clinical Research Organizations (CROs), ensuring we have access to the newest developments, and keeping SourceOne on the cutting edge of the latest scientific discoveries.
Solutions:
SourceOne has taken the lead on the supply of the rapidly evolving category of citrus polymethoxylated flavones (PMF’S), as an ever increasing list of benefits are attributed to these powerful natural citrus extracts. Through its exclusive citrus PMF supply partnership SourceOne is able to guarantee the best source of supply from around the world of the citrus fruits required to extract the PMF’s. SourceOne is also able to provide the most technologically superior and capable extraction, processing, purification and testing processes – resulting in the purest, highest quality, most bio-active PMF’s available. Due to our capabilities, SourceOne is also able to provide customized and, standardized PMF profiles to meet any requirement.
As PMF’s are very poorly absorbed by the body, they are “ideal” ingredients for SourceOne’s patented VESIsorb® naturally assembling association colloid delivery system. A clinical study utilizing SourceOne PMF-source citrus flavonoids with our VESIsorb delivery system is currently under way.
SourceOne is the preeminent supplier of the highest quality citrus PMF’s available and can meet the rapidly growing demand for the many health benefits they deliver alone or in combination in the award winning Cholesstrinol™ heart healthy formulas.
Clinical Science:
More than 25 years of documented epidemiological studies provide evidence that consumption of fruit and vegetables is associated with reduced risk of cardiovascular disease, with citrus flavonoids thought to have a prevalent role. A number of epidemiological studies have shown that consumption of dietary flavonoids is strongly associated with reduced incidence of cardiovascular and coronary problems. Flavonoids and limonoids from citrus have been found to possess anti-inflammatory and cholesterol-lowering properties. Citrus PMFs have been shown to help reduce blood lipids and inhibit early stages of inflammation, a key factor in the early stages of atherosclerotic lesion formation. Flavonoids’ positive effects on health are partly e xplained by their role as antioxidants, and may delay or prevent the onset of diseases related to free radicals. Flavonoids also are considered to have anti-bacterial, anti-viral, and antiallergenic benefits.
Also, in Alternative Therapies in Health and Medicine, November/December, 2007, Vol. 13, No. 6, results were published of several studies that combined PMF-source™ citrus flavonoids and TocoSource® palm tocotrienols. The largest study, a 12-week double-blind, placebo-controlled protocol with 120 subjects, resulted in significant improvements in total cholesterol (-30%), LDL (-27%), and triglycerides (-34%), compared to placebo. In addition, HDL levels increased 4%, resulting in a significant 29% improvement in the LDL:HDL ratio.
Recently, SourceOne announced the results of a study comparing the absorption and bioavailability of PMF-Source™ Citrus Polymethoxylated Flavones with the patented VESIsorb® Delivery System, to standard PMF powder. The bioavailability pilot study (single oral dose, double-blind, crossover design) showed that both Nobiletin and Tangeretin in the standard PMF powder and VESIsorb® formulation were absorbed and extensively metabolized. The PMF absorption of the VESIsorb® formulation was significantly improved and faster (Tmax) compared to the standard PMF powder. Peak plasma levels (Cmax) of Nobiletin, Tangeretin and their metabolites were increased up to 800%.
back to the top